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HomeOral HealthWhat It Is, Advantages, & Greatest Manufacturers ⋆ Ask the Dentist

What It Is, Advantages, & Greatest Manufacturers ⋆ Ask the Dentist

A brand new form of toothpaste has come onto the scene, difficult fluoride’s #1 seat on the cavity-defense desk. However does hydroxyapatite (HAp) actually work to guard and strengthen tooth? Is it secure? Do you have to use it?

On this article, you’ll find out how HAp toothpaste works, why I like to recommend it over fluoride for optimum oral well being, the advantages (together with whiter tooth!), and which manufacturers to attempt.

When you’re carried out with fluoride and able to transfer onto one thing higher and fluoride-free, that is the toothpaste for you.

(Two fast notes: One, within the research I share inside this text, toothpaste is named a “dentifrice” and cavities/tooth decay are known as “dental caries.” Second, after I evaluate HAp to fluoride, I’m referring to topical use solely. As of proper now, there isn’t any different for fluoride in water, as HAp is unstable in water.)


What’s hydroxyapatite?

So, let’s begin with the burning query: What precisely is hydroxyapatite, and why is it in toothpaste?

Hydroxyapatite (HAp), in its pure type, is a type of calcium that makes up 97% of your tooth enamel and 70% of the dentin of your tooth. The remainder of your enamel is definitely composed of water, collagen, and different proteins.

The chemical formulation for hydroxyapatite is Ca5(PO4)3(OH).

Enjoyable reality: hydroxyapatite can also be the key (60%) part of bones. Along with toothpaste, it’s been utilized in osteopathic analysis to assist strengthen bone materials. It additionally exhibits promise for orthodontic restorations.

The excessive HAp focus in tooth enamel is the rationale it’s so sturdy.

Hydroxyapatite Toothpaste for Tooth Remineralization

The principle draw of hydroxyapatite in toothpaste is that it helps to remineralize (rebuild) tooth construction with out any recognized negative effects.

Tooth decay grows and destroys tooth when the remineralization of your tooth outweighs demineralization. Each of those processes occur on a regular basis in your mouth and are impacted by mouth respiratory, your weight-reduction plan, your oral hygiene, and finally, your oral microbiome.

You possibly can heal cavities and forestall new ones from forming by remineralizing your tooth. Hydroxyapatite is one very efficient method to try this.

The rationale most dentists make a giant deal about fluoride is as a result of it’s one of many solely substances on earth that may assist rebuild your tooth. They suppose it’s higher than calcium, because it’s extra proof against acid and fewer more likely to dissolve within the presence of low pH situations.

I clarify the numerous variations between fluoride and HAp later on this article, however the largest drawback with fluoride is that it’s poisonous in massive doses and related to elevated dangers of at the least 11 medical situations.

For essentially the most half, the most important fluoride points should do with ingesting it through water, as most individuals spit out their toothpaste. In case your little one swallows a bit of little bit of toothpaste, it’s normally not going to be a long-term drawback.

Happily, hydroxyapatite is biocompatible together with your tooth — as a result of it’s actually the identical materials as nearly all of your tooth construction!

Not solely is it biocompatible, however it’s completely non-toxic — no Poison Management warning wanted — and strengthens tooth. In actual fact, it’s not simply suitable together with your physique — it’s actually “biomimetic,” which suggests your physique acknowledges it as acquainted construction that belongs there.

The easiest way to make use of hydroxyapatite toothpaste to stop and reverse cavities is to go away it in your tooth after brushing. Translation: Don’t rinse your mouth after brushing with HAp.

How does hydroxyapatite toothpaste work?

HAp acts by changing the minerals your tooth lose once they’re demineralized and filling within the tiny “fissures” or “scratches” in your tooth that in any other case play host to micro organism.

As a result of your tooth acknowledge this compound, they take in and uptake hydroxyapatite right down to the foundation. That is most useful after we’re speaking about tooth decay as a result of HAp can attain down into the furthest space of decay to rebuild enamel on any tooth floor.

The way in which your tooth react to hydroxyapatite toothpaste additionally makes them extra proof against plaque buildup and “acid assaults”/enamel erosion that results in tooth decay. It will possibly even make them look “glossier.”

5 Advantages of Hydroxyapatite for Tooth

1. It will possibly stop and heal cavities.

Each time HAp has been pitted towards fluoride toothpastes, it both performs equally nicely or higher as a remineralizing agent.

It will increase the microhardness of human enamel and prevents and reverses enamel erosion extra successfully than over-the-counter fluoridated toothpaste.

A focus of 10% hydroxyapatite was simply as effective as an amine fluoride toothpaste in a December 2019 research for stopping and reversing tooth decay in kids.

HAp was efficiently in a position to shrink lesions of decay (known as “caries lesions” or “carious lesions”) on tooth and enhance enamel remineralization in a research carried out in Japan. In response to the authors, the extra hydroxyapatite within the toothpaste, the higher it restored the enamel floor.

In 2019, a research discovered that using hydroxyapatite toothpaste really created a coating on the tooth extra sturdy than that shaped by fluoride toothpaste. This helped to strengthen enamel for future resistance to breakdown.

And in contrast to fluoride toothpaste, hydroxyapatite toothpaste gained’t ever trigger fluorosis.

2. It’s non-toxic & biocompatible.

One of many largest drawbacks of fluoride toothpaste is that fluoride, at excessive doses, is a neurotoxicant (a toxin that impacts the mind). Nonetheless, hydroxyapatite toothpaste is a biocompatible substance that your physique acknowledges as one thing that belongs there.

The CDC discovered that the majority children use much more toothpaste than they need to. This can be a massive drawback once you’re speaking about toothpastes with a whole lot of instances the quantity of fluoride than is present in water.

But it surely’s not an issue with HAp.

Hydroxyapatite particles are “biomimetic,” which means they mimic the physique’s personal acquainted supplies. They’re wildly unlikely to trigger any kind of destructive response.

Some sorts of HAp toothpaste are made with nano-hydroxyapatite. This tiny form of particle will not be naturally occurring and must be created synthetically. Nonetheless, there isn’t any proof that these artificial particles are much less biomimetic or poisonous in any method. (You possibly can learn extra about HAp sizes under.)

3. It could assist tooth seem whiter.

With none whitening elements, hydroxyapatite toothpaste might assist to brighten and whiten your tooth.

Toothpaste is, as I’ve stated many instances earlier than, a sharpening dental product. Which means it isn’t obligatory for the disorganization of the micro organism in your tooth (which is the purpose of brushing tooth) however is definitely meant to shine tooth.

It may also be used for added advantages, akin to aiding remineralization (in a method related, however not the identical, to fluoride’s motion).

One among these advantages is an elevated whitening impact. Whereas HAp doesn’t change the “sharpening” exercise of toothpaste, it provides a whitening factor not in any other case seen by commonplace toothpaste.

HAp actually “fills in” the enamel of your tooth with wholesome tooth construction, altering the looks of tooth to be whiter.

4. It’s good for the oral microbiome.

Utilizing HAp toothpaste will assist shield your tooth from “acid assaults” by micro organism, however with out wrecking your oral microbiome. Fluoride, however, is bactericidal and tends to kill off micro organism within the mouth.

Many oral care merchandise suppose that by eliminating micro organism, they’re enhancing the well being of the mouth.

They’re not.

The oral microbiome wants a superb steadiness of micro organism to operate correctly and maintain your mouth wholesome. Brokers like chlorhexidine, alcohol, or triclosan might briefly alleviate bacterial overgrowth issues, however they trigger much more points over time than they assist.

Hydroxyapatite particles in toothpaste stop micro organism from attaching to the enamel of tooth simply as successfully as antibacterial brokers, however with out killing the precise micro organism.

This can be a big profit, as micro organism congregating in your tooth in a single space is what results in “acid assaults” (when micro organism “poop” out the high-carbohydrate meals particles in your mouth). These assaults are what trigger tooth decay.

Not solely does it assist stop acid assaults, it gained’t destroy your valuable oral microbiome.

5. It’s proof against acidic pH.

The pH of the mouth ought to stay barely alkaline to keep away from irritation and oral illness.

HAp toothpaste helps tooth develop into extra proof against acidic pH inside the mouth, which might in any other case dissolve and break down enamel extra rapidly.

6. It could enhance gum well being.

Preliminary outcomes have discovered that using HAp toothpaste might assist enhance gum well being in sufferers with gum illness.

Enhancements seen included plaque management, bleeding gums, and pocket depth.

Micro-Hydroxyapatite vs. Nano-Hydroxyapatite

Hydroxyapatite toothpaste was initially developed synthetically utilizing nano-hydroxyapatite particles. As a result of nano-HAp has been round longer, there’s extra analysis to help its effectiveness.

Nonetheless, micro-hydroxyapatite can also be accessible in some toothpaste manufacturers.

First issues first: each nano- and micro-HAp powerfully remineralize tooth.

Nano-Hydroxyapatite Toothpaste

Toothpastes utilizing nano-Ha have particle sizes between 20-80 nanometers (nm). These are considerably smaller than the dentinal tubules that make up the dentin of your tooth.

Enjoyable reality: The astronauts who first benefited from HAp used nano-hydroxyapatite toothpastes.

Whereas there’s some concern as a result of nano-HAp is “artificial” and “nano” sized, these issues are based mostly on a false premise.

To begin with, the artificial nanoparticles used are not recognized to be harmful in accordance with the a number of research carried out on their security.

Second, high-quality nano-HAp ought to be rod-shaped, not needle-shaped. Most issues round nano elements in cosmetics should do with the way in which these particles can penetrate components of the physique the place they don’t belong, inflicting injury.

Plus, as an additional benefit, nano-hydroxyapatite particles dissolve as quickly as they hit the abdomen. Which means should you swallow a few of your toothpaste, there gained’t be tiny particles going anyplace you don’t need them to go.

The principle good thing about nano-HAp is that it’s probably extra in a position to stop delicate tooth than micro-HAp. The scale of the particles permits it into areas that in any other case might expertise sensitivity to sizzling, chilly, or contact.

One September 2014 research discovered that brushing with a nano-hydroxyapatite toothpaste improved tooth sensitivity equal to a fluoride toothpaste after as little as 2 weeks.

The foremost disadvantage to nano-HAp is that laws don’t permit for very excessive concentrations of it in toothpaste. Subsequently, a nano-HAp toothpaste is unlikely to comprise as a lot of the energetic ingredient as a micro-HAp toothpaste.

Micro-Hydroxyapatite Toothpaste

Micron-sized hydroxyapatite particles are 5-10 microns lengthy, which is bigger than most dentin tubules.

For many who need essentially the most pure toothpaste possibility attainable, micro-HAp stands out as the technique to go.

It’s accessible in larger concentrations of hydroxyapatite and might be derived from all-natural supplies (no synthetics). Even on the smaller dimension, plainly micro-HAp efficiently remineralizes tooth equally to fluoride.

There’s even proof that it may also help with delicate tooth.

Hydroxyapatite vs. Fluoride

When evaluating hydroxyapatite (in nano or micron particles), it persistently performs equally nicely or higher than fluoride. It’s been the go-to possibility in Japan over fluoride toothpastes for over 40 years over sodium fluoride.

These particles work otherwise than fluoride.

Fluoride doesn’t really exchange minerals in your tooth; it creates a brand new construction known as fluorapatite. Fluoride additionally indicators to your enamel, by means of your saliva, to effectively uptake extra calcium and phosphate, strengthening tooth construction.

It kinds its personal distinctive materials known as fluoridated apatite (fluorapatite) above the floor of the tooth, which protects from dental plaque acids.

Each fluoride and hydroxyapatite appear to sluggish or restrict the manufacturing of pathogenic micro organism within the mouth.

Hydroxyapatite can straight exchange the construction misplaced by your tooth throughout demineralization (which is going on consistently, notably should you eat sugary, acidic, or carb-heavy meals). It fills up the microscopic fissures in your enamel created by brushing and different regular put on and tear.

While you brush, HAp can bind with items of plaque or micro organism in order that you find yourself spitting them out, reasonably than letting them stay on the tooth.

As an alternative of forming an exterior layer, like fluoride, HAp reaches down by means of your whole tooth to construct it from the within out. That’s one purpose it’s so nice for cavities — it may well attain the underside of carious lesions the place fluoride can’t contact.

Lastly, HAp ends in smoother, whiter tooth when in comparison with fluoride due to the way it fills the fissures and rebuilds the precise inner construction. In actual fact, it distinctly will increase the microhardness of beforehand demineralized lesions.

Even should you’re nonetheless utilizing fluoride toothpaste, it’s a good suggestion to modify to HAp toothpaste should you’re somebody who could also be at larger threat for fluoride toxicity. This usually contains pregnant mothers, kids, and people who find themselves commercially uncovered to fluoride.

The Greatest Hydroxyapatite Manufacturers

There are two HAp toothpaste manufacturers I like to recommend to readers. I encourage you to examine them out and see which one is best for you.

Boka Ela Mint Toothpaste

RiseWell Mineral Toothpaste

RiseWell Youngsters’ Mineral Toothpaste (birthday cake taste)

RiseWell HAp Floss (the primary ever HAp floss!)


Q: How do you employ hydroxyapatite toothpaste?

A: Identical to any toothpaste, squeeze a pea-sized quantity onto your toothbrush and brush your tooth for at the least 2 minutes.

For finest outcomes, don’t rinse with water after you sweep. This leaves the hydroxyapatite coating in your tooth for the strongest remineralizing impact.

Q: Does HAp toothpaste have negative effects?

A: There are not any recognized negative effects of utilizing HAp toothpaste. In (extremely uncommon) circumstances, folks could also be allergic to those toothpastes, however that’s sometimes because of different elements in a full toothpaste formulation, not the HAp itself.

Q: How lengthy have folks been utilizing this sort of toothpaste?

A: NASA created the primary hydroxyapatite toothpaste in 1970. In 1978, Sangi Co., Ltd. acquired the patent and commenced manufacturing it.

Over the subsequent 30 years or so, Sangi’s toothpaste was studied extensively and beat cavities again and again. Japan’s toothpaste market is dominated by HAp and has been for many years.

In 2015, the primary “cavity-reducing” toothpaste launched with HAp (and with out fluoride) exterior of Japan was X-PUR Remin, offered in Canada.

In 2017, Boka was the primary hydroxyapatite toothpaste model to launch in the US.

Q: Isn’t nano-hydroxyapatite artificial? Why would you suggest an artificial chemical in my toothpaste?

A: Whereas nano-HAp is technically artificial, there isn’t any proof that it’s harmful to human well being.

Q: What does hydroxyapatite toothpaste style like?

A: Relying in your toothpaste model, HAp toothpaste might style like absolutely anything. RiseWell’s children’ taste is a vanilla birthday cake, whereas Boka sticks to the extra conventional mint taste you’re most likely used to in toothpaste.

These flavors are impacted by different elements, akin to xylitol or different sweeteners, important oils, or different flavors.

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